Vacation Rentals in Seneca, South Carolina

50 Properties Available

5? Modern Lakefront Luxury Oasis ?? 270° Lake Views w\/Dock & Hot Tub! Private vacation home
5? Modern Lakefront Luxury Oasis ?? 270° Lake Views w\/Dock & Hot Tub!
$1571 / night
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Keowee's Majestic Mountain View Private vacation home
Keowee's Majestic Mountain View
$1426 / night
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Carolina’s Cottage Cove-Lake Keowee Private vacation home
Carolina’s Cottage Cove-Lake Keowee
$1333 / night
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Luxury Lake Keowee Retreat, Private Dock, Near Clemson - Sleeps 12 Private vacation home
Luxury Lake Keowee Retreat, Private Dock, Near Clemson - Sleeps 12
$1293 / night
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Southern Belle on Keowee w/ Hot Tub Private vacation home
Southern Belle on Keowee w/ Hot Tub
$1128 / night
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Halcyon Heights on Lake Keowee! Private vacation home
Halcyon Heights on Lake Keowee!
$1077 / night
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NEW! Lakefront Seneca Hideaway w\/ Fire Pit & Decks Private vacation home
NEW! Lakefront Seneca Hideaway w\/ Fire Pit & Decks
$1071 / night
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Shoreline Exquisite Reinvented Lake Sanctuary Private vacation home
Shoreline Exquisite Reinvented Lake Sanctuary
$1034 / night
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Beautiful Home on Lake Keowee- Deep Water Dock- 4bd/4ba -Close to Clemson Private vacation home
Beautiful Home on Lake Keowee- Deep Water Dock- 4bd/4ba -Close to Clemson
$923 / night
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Lake Keowee Retreat! Swim, Boat, Kayak & Relax on Dock Just Steps from the Water Private vacation home
Lake Keowee Retreat! Swim, Boat, Kayak & Relax on Dock Just Steps from the Water
$901 / night
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7mi to Clemson Custom Family Luxury Lakehome Game room+ Basketball+ Fire Pit Private vacation home
7mi to Clemson Custom Family Luxury Lakehome Game room+ Basketball+ Fire Pit
$884 / night
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Chartwell Pet Friendly Home in Secluded Cove Private vacation home
Chartwell Pet Friendly Home in Secluded Cove
$870 / night
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Knot On Call Lake House + HOT TUB Private vacation home
Knot On Call Lake House + HOT TUB
$844 / night
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Fall\/Winter Specials! Brand New 6BR\/6BA lakefront. Flat lot\/firepit\/ pool table! Private vacation home
Fall\/Winter Specials! Brand New 6BR\/6BA lakefront. Flat lot\/firepit\/ pool table!
$800 / night
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Lakefront home w\/covered dock*Pool table*Kayak\/SUP*11mi to Clemson*Hot tub Private vacation home
Lakefront home w\/covered dock*Pool table*Kayak\/SUP*11mi to Clemson*Hot tub
$791 / night
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Lakefront luxury on Lake Keowee. Private vacation home
Lakefront luxury on Lake Keowee.
$787 / night
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Lake Keowee Waterfront Clemson Retreat Private vacation home
Lake Keowee Waterfront Clemson Retreat
$766 / night
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Charming 4-bedroom house on Lake Hartwell Private vacation home
Charming 4-bedroom house on Lake Hartwell
$765 / night
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Amazing Waterfront Location on Lake Keowee! Private vacation home
Amazing Waterfront Location on Lake Keowee!
$748 / night
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Serenity Bay on Lake Keowee! Private vacation home
Serenity Bay on Lake Keowee!
$704 / night
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Perfect lake property for Clemson Game Day! Private vacation home
Perfect lake property for Clemson Game Day!
$691 / night
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BIG WATER VIEWS from this waterfront home on Lake Keowee. Close to Clemson. Private vacation home
BIG WATER VIEWS from this waterfront home on Lake Keowee. Close to Clemson.
$687 / night
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Easy access lake front W/ beach & boat ramp, waterfront patio, screened porch Private vacation home
Easy access lake front W/ beach & boat ramp, waterfront patio, screened porch
$685 / night
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Lake Keowee Waterfront Home 15 miles from Clemson! Private vacation home
Lake Keowee Waterfront Home 15 miles from Clemson!
$682 / night
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Lake front house near Clemson University Private vacation home
Lake front house near Clemson University
$654 / night
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Keowee Hideout at Lake Keowee Private vacation home
Keowee Hideout at Lake Keowee
$647 / night
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Clemson Lake House: Game Room & Dock Private vacation home
Clemson Lake House: Game Room & Dock
$646 / night
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New to VRBO! Big water views, private dock, pool table, 15 min Clemson! Private vacation home
New to VRBO! Big water views, private dock, pool table, 15 min Clemson!
$641 / night
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Welcome to “Tiger Haven” 4 Bed 4 Bath Ultimate Clemson Condo Lake Hartwell Condo
Welcome to “Tiger Haven” 4 Bed 4 Bath Ultimate Clemson Condo Lake Hartwell
$597 / night
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Game time! Book your home game stay today! Private vacation home
Game time! Book your home game stay today!
$585 / night
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20 Minutes to Clemson - Remodeled 4 BR/3 BA Waterfront Private vacation home
20 Minutes to Clemson - Remodeled 4 BR/3 BA Waterfront
$565 / night
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Private Peninsula on Lake Keowee. Private vacation home
Private Peninsula on Lake Keowee.
$562 / night
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WHITE SAND BEACH-DEEP WATER DOCK 23FT-UV HVAC-FIRE RING Private vacation home
WHITE SAND BEACH-DEEP WATER DOCK 23FT-UV HVAC-FIRE RING
$559 / night
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Lakefront Fun Near Clemson! Retreat w/ Pool Access Private vacation home
Lakefront Fun Near Clemson! Retreat w/ Pool Access
$554 / night
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Cozy Log Cabin near Clemson with Big Water Views Cabin
Cozy Log Cabin near Clemson with Big Water Views
$550 / night
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Lakefront Seneca Vacation Rental w/ Shared Dock! Apartment
Lakefront Seneca Vacation Rental w/ Shared Dock!
$548 / night
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Perfect Summer get away! Charming 4 bedroom lake front home. Private vacation home
Perfect Summer get away! Charming 4 bedroom lake front home.
$548 / night
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What a perfect location for couples and families to gather on Lake Keowee. This beautiful lake fr... Private vacation home
What a perfect location for couples and families to gather on Lake Keowee. This beautiful lake fr...
$547 / night
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Lake Front, Quiet, Private cove on 4.75 acres, Canoe, 2 Kayak, 2 boat docks Private vacation home
Lake Front, Quiet, Private cove on 4.75 acres, Canoe, 2 Kayak, 2 boat docks
$518 / night
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6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water. Private vacation home
6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.
$517 / night
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Lake Front Hartwell House 4.5 Miles to Clemson. 5 Bedrooms 3 Full Baths.14 Beds Private vacation home
Lake Front Hartwell House 4.5 Miles to Clemson. 5 Bedrooms 3 Full Baths.14 Beds
$508 / night
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Sparrow's Haven Private vacation home
Sparrow's Haven
$508 / night
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Clemson\/Lake Hartwell house - big water views, dock, 10 minutes to Clemson Private vacation home
Clemson\/Lake Hartwell house - big water views, dock, 10 minutes to Clemson
$507 / night
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Beautiful Lakefront Rental on Lake Keowee near Clemson. Pets welcome! Private vacation home
Beautiful Lakefront Rental on Lake Keowee near Clemson. Pets welcome!
$506 / night
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Beautiful Waterfront Retreat on Lake Keowee W\/ Clemson game day parking pass Guest house
Beautiful Waterfront Retreat on Lake Keowee W\/ Clemson game day parking pass
$504 / night
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**Beautiful Lake Keowee Home Sleeps 15 ** GET AWAY AND RELAX!! Private vacation home
**Beautiful Lake Keowee Home Sleeps 15 ** GET AWAY AND RELAX!!
$499 / night
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Lakefront Keowee Luxury Cottages 127 Private vacation home
Lakefront Keowee Luxury Cottages 127
$483 / night
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Lakefront Keowee Luxury Cottages 129 Cottage
Lakefront Keowee Luxury Cottages 129
$483 / night
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Seneca Vacation Rental < 1 to Lake Keowee Access! Private vacation home
Seneca Vacation Rental < 1 to Lake Keowee Access!
$472 / night
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Spectacular lake home with dock and fire pit- room for all - good pets ok- Private vacation home
Spectacular lake home with dock and fire pit- room for all - good pets ok-
$470 / night
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